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目的分析孕妇乙型肝炎病毒(HBV)感染模式及感染相关状况与新生儿宫内感染的临床关系,为治疗孕妇HBV感染提供参考依据。方法选取2013年10月-2014年12月医院HBV感染的40例孕妇患者为研究对象,采取ELISA检测孕妇以及新生儿的乙型肝炎血清标志物(HBVM),使用PCR检测外周血单核细胞(PBMC)内HBV-DNA的相关指标。结果 40例孕妇HBV患者的总感染率为10.23%,孕妇HBV感染模式中约有12种,孕妇HBV阳性感染率为10.11%;6种模式中以小三阳模式最为多见,占总比例的97.88%,小三阳的孕妇HBV检出率为20.58%,大三阳的孕妇HBV检出率为96.35%,两组数据比较差异有统计学意义(P<0.05)。结论 40例研究对象中存在一定程度HBV感染,以小三阳模式最为常见。
Objective To analyze the relationship between hepatitis B virus (HBV) infection patterns and infection-related status in pregnant women and intrauterine infection in neonates, and to provide a reference for the treatment of HBV infection in pregnant women. Methods Forty pregnant women with HBV infection from October 2013 to December 2014 in our hospital were enrolled in this study. Serum markers of hepatitis B (HBVM) in pregnant women and newborns were detected by ELISA and peripheral blood mononuclear cells PBMC) HBV-DNA related indicators. Results The total infection rate of HBV infection in 40 pregnant women was 10.23%, HBV infection rate in pregnant women was about 12, and the positive rate of HBV infection in pregnant women was 10.11%. Among the 6 modes, the positive rate of HBV infection was the most common, accounting for 97.88 The detection rate of HBV in pregnant women was 20.58%. The detection rate of HBV in pregnant women with big three positives was 96.35%. There was significant difference between the two groups (P <0.05). Conclusions There are some HBV infection in 40 cases and the most common pattern is small Sanyang model.