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目的研究双心疗法治疗急性冠脉综合征(ACS)患者的疗效。方法选择ACS患者138例,随机分为研究组69例和对照组69例,所有病例均给予常规心血管药物规范性治疗。治疗组在规范治疗基础上加用心理干预治疗,包括药物治疗和认知治疗、行为干预、生物反馈放松治疗,其中药物治疗用盐酸舍曲林和氯硝安定。观察两组用药3个月后,患者ACS症状的改善情况以及用药期间的不良反应。结果①ACS症状的改善情况:研究组总有效率为95.65%;对照组总有效率为76.81%。研究组与对照组相比,差异有统计学意义(P<0.05)。②不良反应:两组用药期间均未见药物不良反应,无意外死亡病例。结论双心疗法治疗急性冠脉综合征患者安全、有效、可行,而且比常规规范治疗更有效,但尚需进行大样本的循证研究来更完善地进一步深入探讨。
Objective To study the effect of bivetreatment on patients with acute coronary syndrome (ACS). Methods A total of 138 ACS patients were selected and randomly divided into study group (69 cases) and control group (69 cases). All cases were given routine cardiovascular drugs. The treatment group was treated with psychological intervention on the basis of standard treatment, including drug therapy and cognitive therapy, behavioral intervention, relaxation therapy with biofeedback, and sertraline and clonazepam hydrochloride for drug therapy. After three months of treatment, the improvement of symptoms of ACS and the adverse reactions during the treatment were observed. Results ① The improvement of symptoms of ACS: The total effective rate was 95.65% in the study group and 76.81% in the control group. The difference between the study group and the control group was statistically significant (P <0.05). Adverse reactions: No drug adverse reactions were observed during the two groups, and no accidental deaths occurred. Conclusions Biventricular-based therapy is safe, effective and feasible for the treatment of patients with acute coronary syndromes. It is more effective than routine normative treatment. However, evidence-based studies of large samples are still needed to further explore these two aspects.