论文部分内容阅读
实验比较了正常（１６例）及妊高征患者（２３例）胎盘ＡｎｇⅡ，肾素活性及母体和胎儿红细胞膜钙泵活性的变化及后者对某些活性物质，包括钙调素（Ｃａｌｍｏｄｕｌｉｎ，ＣａＭ）和人红细胞抗高血压因子（ＡＨＦ）刺激的反应性。结果表明：１．与正常孕妇比较，妊高征患者胎盘ＡｎｇⅡ水平明显升高，肾素活性无显著改变；ＡＨＦ（１０４ｇ／ｍｌ）对正常孕妇及妊高征患者胎盘肾素活性未见明显影响；２．妊高征母体及胎儿红细胞膜Ｍｇ２＋ＡＴＰ酶活性均显著降低，加ＡＨＦ后，钙泵活性在妊高征母体及胎儿明显低于正常妊娠母体（ｐ＜００１）和胎儿（ｐ＜００５）。提示：胎盘ＡｎｇⅡ水平改变及细胞膜上钙泵对某些物质的反应性发生改变可能与妊高征发病有关
The experiment compared the changes of Ang Ⅱ, renin activity and calcium pump activity of maternal and fetal erythrocyte membrane in normal (16 cases) and pregnancy induced hypertension patients (23 cases), and the latter compared the changes of some active substances including calmodulin CaM) and human erythrocyte antihypertensive factor (AHF) stimuli. The result shows: 1. Compared with normal pregnant women, placental AngⅡlevels in patients with PIH were significantly increased, and there was no significant change in renin activity; AHF (10-4g / ml) had no significant effect on placental renin activity in normal pregnant women and PIH patients.2. Pregnancy-induced hypertension and maternal fetal membranes and fetal membranes of erythrocyte membrane Mg2 ATP activity were significantly reduced, plus the AHF, calcium pump activity in the PIH maternal and fetal significantly lower than the normal pregnant women (p <0 01) and the fetus (p <0 05). Tip: changes in the level of placental Ang Ⅱ and the membrane calcium on the reactivity of some substances may be related to the pathogenesis of pregnancy-induced hypertension