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目的:研究双氢青蒿素抬疗实验大鼠卡氏肺抱子虫肺炎的疗效。方法:Wi丑ar大鼠皮下注射醋酸可的松建立卡氏肺泡子虫肺炎动物模型。用双氢青蒿素治疗实验大鼠同时设有感染组和正常组作为对照。通过存活数、存活率、肺重、肺重/体树重比、包囊计数和肺组织病理学变化考核药物疗效。结果:治疗组大鼠存活数、存活率均高于感染组,而低于正常组;治疗组大鼠平均肺重、平均肺重/体重比和包囊数均低于感染组,肺组织炎症反应明显减轻。结论:双氢青蒿素是一种治疗大鼠卡氏肺孢子虫肺炎的有效药物。
Objective: To study the therapeutic effect of dihydroartemisinin on rats with Ccarotrichum pneumoniae pneumonia. Methods: The rat model of Alzheimer’s disease pneumonia was established by subcutaneous injection of cortisone acetate in rats. With dihydroartemisinin treatment of experimental rats with infection and normal group as a control. The drug efficacy was evaluated by survival, survival, lung weight, lung weight / body weight ratio, cyst count and lung histopathology. Results: The survival rate and survival rate of treatment group were higher than those of infection group and lower than those of normal group. The average lung weight, average lung weight / body weight ratio and number of cysts in treatment group were lower than those in infection group and lung tissue Response significantly reduced. Conclusion: Dihydroartemisinin is an effective drug for the treatment of pneumocystis carinii pneumonia in rats.