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目的探讨妊娠晚期几种常见的生殖道病原微生物感染与妊娠结局的相关性。方法选取2013年1月至2015年4月新疆医科大学第二附属医院收治的妊娠晚期生殖道病原微生物感染患者633例作为观察组,同时随机选取同期病原体检测阴性者413例作为对照组,比较两组不良妊娠结局的发生情况。结果经过临床实验室检查,观察组中病原微生物培养情况分布以支原体感染491例(46.94%)、假丝酵母菌感染195例(18.64%)两种较为多见,观察组中支原体感染者胎膜早破、产褥感染、新生儿感染(χ2=65.44,P<0.05);衣原体感染者早产、产褥感染(χ2=72.87,P<0.05);滴虫感染者胎膜早破、产褥感染(χ2=24.20,P<0.05);假丝酵母菌感染者早产、胎膜早破、产褥感染、胎儿窘迫、新生儿感染率(χ2=71.76,P<0.05)明显高于对照组,差异有统计学意义。剖宫产率及新生儿窒息率的比较差异无统计学意义(χ2=1.04,P>0.05)。而多重与单一病原体感染比较,除早产外其余妊娠结局差异无统计学意义(χ2=73.08,P<0.05)。结论妊娠晚期生殖道病原微生物感染,会增加不良妊娠结局的发生率,应引起围产妇及临床医师的重视,适时进行干预减少不良结局的发生。
Objective To explore the correlation between several common pregnancy pathogenic microorganisms and pregnancy outcome in late pregnancy. Methods From January 2013 to April 2015, 633 cases of genital tract infection caused by genital tract infection in the third trimester of pregnancy admitted to the Second Affiliated Hospital of Xinjiang Medical University were selected as the observation group. 413 cases of negative pathogen detection at the same time were randomly selected as the control group. Group adverse pregnancy outcome of the situation. Results After clinical laboratory examination, there were 491 cases (46.94%) of mycoplasma infection and 195 (18.64%) cases of Candida infection in the observation group. The mycoplasma infection (Χ2 = 65.44, P <0.05). Chlamydial infection was premature and puerperal infection (χ2 = 72.87, P <0.05). The incidence of premature rupture of membranes, puerperal infection (χ2 = 24.20, P <0.05). The prevalence of preterm birth, premature rupture of membranes, puerperal infection, fetal distress and neonatal infection rate was significantly higher in patients with Candida infection than those in the control group (χ2 = 71.76, P <0.05) There is statistical significance. There was no significant difference in cesarean section rate and neonatal asphyxia (χ2 = 1.04, P> 0.05). The multiple and single pathogen infection, except for preterm labor, the rest of the pregnancy outcome difference was not statistically significant (χ2 = 73.08, P <0.05). Conclusion The infection of pathogenic microorganisms in the third trimester of pregnancy increases the incidence of adverse pregnancy outcomes and should be paid attention to by perinatal women and clinicians. Interventions should be taken to reduce the incidence of adverse outcomes.