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目的探讨高敏C反应蛋白(hypersensitivity C-reactive protein,hs-CRP)及血压变异性与经皮冠状动脉介入术后心肌重构的关系。方法行经皮冠状动脉介入术治疗的慢性稳定性心绞痛患者43例,依据术前hs-CRP水平分为低hs-CRP组(hs-CRP≤3mg/L)20例,高hs-CRP组(hs-CRP>3mg/L)23例。分别于术前及术后12个月行超声心动图检查,测定左心室舒张末期内径、左心室舒张末期容积、左心室收缩末期容积及左心室射血分数,并进行比较。结果 hs-CRP与血压变异性呈正相关;2组治疗后左心室舒张末期容积、左心室收缩末期容积、左心室射血分数均较治疗前增高(P<0.05);高hs-CRP组左心室舒张末期内径较治疗前增大明显(P<0.05)。结论 hs-CRP与血压变异性呈正相关,与患者术后心肌重构有相关性。
Objective To investigate the relationship between high-sensitivity C-reactive protein (hs-CRP) and variability of blood pressure and myocardial remodeling after percutaneous coronary intervention. Methods Forty-three patients with chronic stable angina pectoris underwent percutaneous coronary intervention were divided into low hs-CRP group (hs-CRP≤3mg / L), 20 cases of high hs-CRP group (hs -CRP> 3mg / L) in 23 cases. Echocardiography was performed before and 12 months after operation. The left ventricular end diastolic dimension, left ventricular end-diastolic volume, left ventricular end-systolic volume and left ventricular ejection fraction were measured and compared. Results There was a positive correlation between hs-CRP and variability of blood pressure. Left ventricular end-diastolic volume, left ventricular end-systolic volume and left ventricular ejection fraction were significantly increased in both groups (P <0.05) End diastolic diameter increased significantly than before treatment (P <0.05). Conclusions There is a positive correlation between hs-CRP and variability of blood pressure, which correlates with postoperative myocardial remodeling.