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目的探讨急性脑梗死患者同型半胱氨酸(Hcy)和超敏C反应蛋白(hs-CRP)的变化及其临床意义。方法经CT或MRI确诊的263例急性脑梗死患者为病例组,107例健康查体者作为对照组,采用免疫透射比浊法和ELISA法分别测定血清hs-CRP和血浆Hcy水平。结果急性脑梗死患者血Hcy和hs-CRP水平均明显高于对照组(P<0.01);Hcy与hs-CRP水平依照LACI、POCI、PACI、TACI亚型排序逐渐增高(P<0.05,P<0.01),与疾病的严重程度呈现明显的正相关(r=0.43和r=0.52)。结论急性脑梗死患者Hcy和hs-CRP明显升高,并且与脑梗死的严重程度呈正相关,可作为预测急性脑梗死发生发展的敏感指标。
Objective To investigate the changes of homocysteine (Hcy) and hypersensitive C-reactive protein (hs-CRP) in patients with acute cerebral infarction and its clinical significance. Methods Totally 263 patients with acute cerebral infarction confirmed by CT or MRI were selected as the case group and 107 healthy individuals as the control group. Serum hs-CRP and plasma Hcy levels were measured by immunoturbidimetry and ELISA respectively. Results The levels of Hcy and hs-CRP in patients with acute cerebral infarction were significantly higher than those in control group (P <0.01). The levels of Hcy and hs-CRP were increased in accordance with LACI, POCI, PACI and TACI subtypes (P <0.05, P < 0.01), and the severity of the disease showed a significant positive correlation (r = 0.43 and r = 0.52). Conclusions Hcy and hs-CRP in patients with acute cerebral infarction are significantly increased, and are positively correlated with the severity of cerebral infarction, which may be used as a sensitive index to predict the occurrence and development of acute cerebral infarction.