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目的:探讨奥美拉唑联合莫沙必利治疗反流性食管炎的临床效果。方法:回顾性分析2010年10月～2011年10月间我院治疗的反流性食管炎120例患者的临床资料,将患者随机分为治疗组和对照组,每组各60例。治疗组口服奥美拉唑20mg/次,2次/天,口服莫沙必利5mg/次,3次/天。对照组单纯口服奥美拉唑20mg/次,2次/天。治疗8周为1个疗程。结果:观察组治疗总有效率为96.67%(58/60)明显高于对照组治疗总有效率81.6(749/60),差异有显著性,P<0.05。观察组1d、3d和8周时的疼痛缓解率明显高于同期对照组水平,P<0.05。两组患者治疗过程中少数患者出现轻度腹泻和皮肤过敏,无其他不良反应。结论:奥美拉唑联合莫沙必利治疗反流性食管炎是一种有效的治疗方案,不良反应少,值得临床广泛推广。
Objective: To investigate the clinical effects of omeprazole and mosapride in the treatment of reflux esophagitis. Methods: The clinical data of 120 patients with reflux esophagitis treated in our hospital from October 2010 to October 2011 were retrospectively analyzed. The patients were randomly divided into treatment group and control group, with 60 cases in each group. The treatment group omeprazole 20mg / time, 2 times / day, oral mosapride 5mg / time, 3 times / day. Control group omeprazole alone oral 20mg / time, 2 times / day. Treatment for 8 weeks for a course of treatment. Results: The total effective rate of the observation group was 96.67% (58/60), which was significantly higher than that of the control group (81.6%, 749/60). The difference was significant (P <0.05). Pain relief rates at 1, 3 and 8 weeks in the observation group were significantly higher than those in the control group at the same period (P <0.05). A small number of patients in the two groups of patients with mild diarrhea and skin allergies, no other adverse reactions. Conclusion: Omeprazole combined with mosapride in the treatment of reflux esophagitis is an effective treatment regimen with few adverse reactions, which deserves wide clinical application.