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目的探讨血清降钙素原(PCT)在慢性阻塞性肺疾病急性加重期(AECOPD)优化抗生素应用中的价值。方法 80例AECOPD患者随机分为观察组和对照组,各40例,对照组根据经验使用抗生素,观察组根据血清PCT水平指导抗生素应用。当血清PCT≥0.25 ng/ml时,进行抗生素治疗,当PCT<0.25 ng/ml时,则停止使用抗生素治疗。并观察两组患者抗生素的使用疗程,抗生素所用费用及住院时间。结果观察组患者抗菌药物疗程、抗生素使用费用、住院费用及二重感染率明显低于对照组,差异有统计学意义(P<0.05)。两组的住院时间及临床有效率比较差异无统计学意义(P>0.05)。结论 AECOPD患者根据PCT水平使用抗生素,能较明显缩短抗生素的使用疗程,减少医疗费用,有效防止抗生素过度使用。
Objective To investigate the value of serum procalcitonin (PCT) in optimizing the application of antibiotics in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods 80 patients with AECOPD were randomly divided into observation group and control group, 40 cases in each group. The control group used antibiotics according to experience and the observation group guided the antibiotic application according to serum PCT level. Antibiotics were given when serum PCT> 0.25 ng / ml, and antibiotics were discontinued when PCT <0.25 ng / ml. Antibiotics treatment course, antibiotic cost and hospital stay were observed in two groups. Results The antibacterial treatment, antibiotic use cost, hospitalization cost and double infection rate in observation group were significantly lower than those in control group (P <0.05). There was no significant difference in hospitalization time and clinical efficiency between the two groups (P> 0.05). Conclusion The use of antibiotics in patients with AECOPD according to the PCT level can significantly shorten the course of antibiotic use, reduce medical costs and effectively prevent overuse of antibiotics.