Purpose: To evaluate the neuroprotective effect of Minocycline on retinal ganglion cells (RGCs) survival after optic nerve tran-section in rats. Minocycline is commonly used by humans, because of its beneficial antimicrobial and anti-inflammatory actions. Recently, it was shown that it has remarkable neuroprotective qualities in animal models of cerebral ischemia, traumatic Purpose: To evaluate the neuroprotective effect of Minocycline on retinal ganglion cells (RGCs) survival after optic nerve tran-section in rats. Because it’s beneficial antimicrobial and anti-inflammatory actions. Recently, it was shown that it has remarkable neuroprotective qualities in animal models of cerebral ischemia, traumatic