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目的观察高渗盐水与布地奈德混悬液氧气雾化吸入治疗毛细支气管炎的效果。方法将2012年10月—2014年3月儿科住院收治的148例毛细支气管炎患儿随机分为2组,分别为治疗组:高渗盐水与布地奈德混悬液氧气雾化治疗74例,布地奈德1mg+3%氯化钠液2ml,2次/d;对照组:布地奈德混悬液氧气雾化治疗74例,布地奈德1mg,2次/d,雾化治疗5d,比较两组患儿的临床症状和体征消失时间、住院时间、临床疗效等指标,计量资料以±s表示,采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果治疗组患儿治疗组7d内咳嗽、喘憋、肺部湿啰音消失时间及住院时间均比对照组明显缩短[(4.94±1.02)、(2.55±0.98)、(3.72±0.90)、(5.94±1.15)、(6.53±2.07)、(4.76±2.01)、(5.77±1.30)、(8.55±1.96)d],差异均有统计学意义(均P<0.05)。结论高渗盐水与布地奈德混悬液氧气雾化用予治疗毛细支气管炎,具有临床症状缓解率高,方便安全等特点,值得临床推广。
Objective To observe the effect of inhalation of hypertonic saline and budesonide aerosol on bronchiolitis. Methods A total of 148 children with bronchiolitis who were hospitalized in pediatrics from October 2012 to March 2014 were randomly divided into two groups: treatment group (74 cases) treated with oxygen atomization with hypertonic saline and budesonide suspension, Budesonide 1mg + 3% sodium chloride solution 2ml, 2 times / d; control group: budesonide suspension oxygen atomization treatment 74 cases, budesonide 1mg, 2 times / d, atomization for 5 days, Two groups of children with clinical symptoms and signs of disappearance of time, hospital stay, clinical efficacy and other indicators, measurement data to ± s, using t test, count data using χ2 test, P <0.05 was considered statistically significant. Results The cough, wheezing, disappearance of pulmonary wet rales and hospital stay in treatment group were significantly shorter than those in control group within 7 days (4.94 ± 1.02, 2.55 ± 0.98, 3.72 ± 0.90, 5.94 ± 1.15, 6.53 ± 2.07, 4.76 ± 2.01, 5.77 ± 1.30, 8.55 ± 1.96, respectively) (all P <0.05). Conclusion The treatment of bronchiolitis with hypertonic saline and budesonide suspension by aerosolization has the characteristics of high clinical remission rate, safety and convenience, which is worthy of clinical promotion.