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美多心安是一种新型β受体阻滞剂,对高血压、心绞痛均具有良好的疗效。为了提高其疗效,减少毒副作用,临床上常与其他药物合并应用,现将其药物相互作用综述如下: 美多心安与氯噻酮文献指出,二者合并使用时,降压效果明显增大,可持续24 h,而且夜间比白天血压减低值明显增大(P<0.001) 美多心安与硝酸异山梨醇酯据报道,二者合并使用时对心绞痛的疗效不佳,并不能减少心绞痛发作的次数,也未能减少硝酸异山梨醇酯的剂量,且可使左室球泵功能恶化。美多心安与异搏定二者合并使用时,异搏定能使美多心安的血药浓度和时间-血药浓度曲线下面积(AUC)增加并能减少美多心安的消除,如服美多心安100mg/次,8 h一次,合并使用异搏定120mg/次,每8h一次。8 h后,美多心安的AUC
The United States and more peace of mind is a new type of β-blockers, hypertension, angina have a good effect. In order to improve its curative effect, reduce the toxic and side effects, often combined with other drugs in clinical practice, now the drug interactions are summarized as follows: Metoprolol and chlorthalidone literature pointed out that the combination of the two, the antihypertensive effect was significantly increased, Sustained 24 h, and nighttime blood pressure decreased significantly higher than during the daytime (P <0.001) Metoprolol and isosorbide mononitrate reportedly, the two combined use of angina pectoris is not good, and can not reduce the incidence of angina pectoris Also failed to reduce the dosage of isosorbide dinitrate, and could worsen the left ventricular pump function. The United States and more peace of mind and verapamil when the combination of the two, verapamil will enable the United States and more peace of mind serum concentration and time - blood concentration curve under the area (AUC) increased and can reduce the elimination of the United States and more peace of mind, such as the United States More heart security 100mg / time, 8 h once, combined with verapamil 120mg / time, once every 8h. After 8 h, the United States and more peace of mind AUC