目的　研究美洛昔康体外和体内给药对免疫活性的调节作用。方法　小鼠体外脾淋巴细胞增殖实验和腹腔巨噬细胞 (MΦ )产生白细胞介素 1(IL - 1)实验以及大鼠佐剂性关节炎模型。结果　不同浓度美洛昔康体内、外给药 ,对脾淋巴细胞增殖、腹腔 MΦ产生 IL - 1和对足爪肿胀的抑制作用 ,均随药物剂量增大而增强 ,且呈剂量依赖性。结论　美洛昔康对免疫活性具有负性调节作用 Objective To study the regulatory effect of meloxicam administered in vitro and in vivo on immunocompetence. Methods Splenic lymphocyte proliferation in vitro and interleukin - 1 (IL - 1) production in peritoneal macrophages (MΦ) and adjuvant arthritis in rats were studied. Results In vitro and in vivo administration of meloxicam at different concentrations showed a dose - dependent effect on the proliferation of splenic lymphocytes, production of IL - 1 by peritoneal MΦ and swelling of paw. Conclusion Meloxicam has a negative regulatory effect on immune activity