论文部分内容阅读
为了探讨经Ｘ－刀治疗后脑胶质瘤中ＰＣＮＡ和ｐ５３基因表达的变化，作者采用组织免疫组化ＡＢＣ法，检测３６例经Ｘ－刀治疗后脑胶质瘤和３０例对照组的标本，分别计算增殖细胞核抗原标记率（ＰＣＮＡ－ＬＩ）和ｐ５３基因表达标记率（ｐ５３－ＬＩ）。结果表明，治疗组的ＰＣＮＡ－ＬＩ明显低于对照组（Ｐ＜０．０５），治疗组的ｐ５３－ＬＩ明显高于对照组（Ｐ＜０．０５）；治疗组和对照组内ＰＣＮＡ与ｐ５３基因的表达均呈显著性正相关关系。作者认为，ＰＣＮＡ和ｐ５３基因的表达可作为脑胶质瘤对放射敏感性和恶性程度的标志之一。
To investigate the changes of PCNA and p53 gene expression in brain glioma after X-knife treatment, the authors used tissue-immunohistochemical ABC method to detect 36 cases of glioma after X-knife treatment and 30 cases of control group, respectively. The proliferating cell nuclear antigen labeling rate (PCNA-LI) and the p53 gene expression labeling rate (p53-LI) were calculated. The results showed that the PCNA-LI of the treatment group was significantly lower than that of the control group (P<0.05). The p53-LI of the treatment group was significantly higher than that of the control group (P<0.05); PCNA and p53 in the treatment and control groups. Gene expression showed a significant positive correlation. The authors believe that the expression of PCNA and p53 gene can be used as one of the hallmarks of gliomas for radiosensitivity and malignancy.