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脑红蛋白是继血红蛋白和肌红蛋白后由Burmester等[1]于2000年发现的体内第3类携氧蛋白,脑红蛋白在视网膜组织中的含量高达100μmol/L,占视网膜总蛋白量的2%-4%,其浓度约为脑中浓度的100倍,而体内不同组织脑红蛋白表达量的增加均与组织的缺血缺氧密切相关。视网膜作为中枢神经系统的重要组成部分之一,对氧的需求远远大于其他神经组织,临床实践中存在着与视网膜相关的大量的缺血缺氧性疾病,视网膜的这种特征为我们深入研究脑红蛋白与视网膜细胞之间的关系提供了临床基础。本文就脑红蛋白在缺血缺氧疾病中的表达展开论述,为视网膜缺血缺氧损伤中脑红蛋白的表达提供相关依据。
Neuroglobin is the third type of oxygen-carrying protein in the body discovered by Burmester et al [1] in 2000 after hemoglobin and myoglobin. The content of neuroglobin in retinal tissue is as high as 100 μmol / L, accounting for the total amount of retinal protein 2% -4%, its concentration is about 100 times the brain concentration, while the increase of different organizations in vivo brain protein expression are closely related with tissue ischemia and hypoxia. Retina as an important part of the central nervous system, the demand for oxygen is much larger than other neural tissues, there are a large number of retina-related hypoxic-ischemic disease in clinical practice, this feature of the retina for our in-depth study The relationship between neuroglobin and retinal cells provides the clinical basis. This article discusses the expression of neuroglobin in ischemic and hypoxic-ischemic encephalopathy, and provides the basis for the expression of neuroglobin in retinal ischemia-hypoxic injury.