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临床上在治疗甲状腺危象和甲状腺功能亢进(甲亢)行紧急手术前,往往需用稳定的碘制剂加抗甲状腺药物,以迅速降低血清甲状腺激素及控制临床症状。已有报告含碘的口服胆囊造影剂如胺碘苯丙酸钠(sodium ipodate)能单独或与其它药物联合用于治疗甲亢。其原理是碘能抑制甲状腺素(T_4)、反-三碘甲腺原氨酸(rT_3)的外环5′位脱碘,并阻滞甲状腺激素的释放。本文报告三组药物:①他巴唑;②他巴唑+胺碘苯丙酸钠;③他巴唑+饱和碘化钾溶液用于短期治疗甲亢 Graves 病,并比较其疗效。_
Clinically in the treatment of thyroid crisis and hyperthyroidism (hyperthyroidism) line emergency surgery, often require the use of stable iodine agents plus anti-thyroid drugs to rapidly reduce serum thyroid hormone and control of clinical symptoms. It has been reported that iodine-containing oral gall bladder contrast agents, such as sodium ipodate alone or in combination with other drugs, can be used to treat hyperthyroidism. The principle is that iodine can inhibit thyroid hormone (T_4), anti-triiodothyronine (rT_3) outer ring 5 ’deiodination, and block the release of thyroid hormone. This article reports three groups of drugs: (1) methimazole; (2) methimazole and amiodarone sodium propionate; (3) methimazole and saturated potassium iodide solution for the short-term treatment of hyperthyroidism Graves disease and to compare its efficacy. _