本文总结口服胺碘酮转复持续性房颤７０例的疗效，分析影响疗效的因素和毒副反应。结果：总有效率为７４．３％（５２／７０）。患者年龄、基础心脏病、左房内径大小对复律成功与否无影响。有影响的因素为房颤持续时间和心功能状态。用药后房颤的ｆ波幅升高，频率减慢，提示心功能改善，可预告复律将成功。胺碘酮的毒副反应轻，发生率低。但长期应用要警惕潜在的肺、肝和神经系统的严重毒性作用 This article summarizes the efficacy of oral amiodarone in the treatment of 70 cases of persistent atrial fibrillation, analysis of the factors that affect the efficacy and toxicity. Results: The total effective rate was 74.3% (52/70). The patient’s age, basic heart disease and left atrial diameter had no effect on the success of cardioversion. Influential factors are the duration of AF and cardiac function status. AF after treatment of atrial fibrillation amplitude increased, the frequency of slowing, suggesting improvement in cardiac function, cardioversion can be expected to be successful. Amiodarone toxicity, low incidence. However, long-term application should be wary of the potential serious toxic effects of lung, liver and nervous system