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目的探讨全自动毛细管血红蛋白电泳法对育龄夫妇地中海贫血筛查的诊断价值。方法选取2014年6月至2016年3月参加黔南州地中海贫血防控试点县级医疗机构送检符合地中海贫血筛查对象的17936例育龄夫妇孕前标本,进行毛细管血红蛋白电泳测试,观察血红蛋白的异常组分布情况,进行分型;同时与血液常规检测、基因诊断比较分析。结果地中海贫血电泳筛查表型阳性对象中,毛细管电泳对α-地中海贫血筛查阳性率显著高于血常规筛查;对β-地中海贫血筛查阳性率与血常规筛查无显著性差异。结论全自动毛细管血红蛋白电泳在地中海贫血筛查中有较高价值,尤其是对β-地中海贫血筛查的准确率高于血常规筛查,能够为育龄夫妇孕前地中海贫血筛查提供可靠依据,值得推广。
Objective To investigate the diagnostic value of automatic capillary hemoglobin electrophoresis in the screening of thalassemia in couples of childbearing age. Methods From Jun. 2014 to Mar. 2016, participants participated in Qiannan Prefecture Thalassemia prevention and control pilot county level medical institutions to examine 17,936 couples of couples of adolescents who had been eligible for thalassemia screening for preconception samples for capillary hemoglobin electrophoresis and to observe hemoglobin abnormalities Group distribution, classification; the same time with the blood test, genetic diagnosis comparative analysis. Results In thalassemia electrophoresis screening positive phenotype, the positive rate of α-thalassemia screening by capillary electrophoresis was significantly higher than that of blood routine screening. The positive rate of beta-thalassemia screening was not significantly different from that of blood routine screening. Conclusion The automatic capillary hemoglobin electrophoresis has high value in thalassemia screening. Especially, the accuracy of β-thalassemia screening is higher than that of routine blood screening, which can provide a reliable basis for the screening of pre-pregnancy thalassemia in couples of childbearing age. Promotion.