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一定浓度的芦笋原汁(Asparagus Officinalis Linn)对小鼠肺腺癌(LA-795)、人鼻咽癌(CNE)、人宫颈癌(HeLa)和人食管癌(Eca109)离体细胞有明显的细胞毒性作用。对克隆源性细胞的杀伤程度与芦笋汁浓度和接触时间成正相关。各细胞系药敏反应不同,LA-795细胞最为敏感(D_o=1.3%),CNE和HeLa细胞次之(D_o=2.1%和2.6%),Eca109细胞较不敏感(D_o=4.4%)。芦笋精对LA-739小鼠肺腺癌实体瘤有抑制生长作用。肿瘤体积测定表明芦笋精使肿瘤平均倍增时间延迟了四天,抑瘤效力为1.5左右。低浓度芦笋原汁(1.0%-0.1%)可促进外周血T淋巴细胞转化增殖,是机体免疫功能的生物调节剂。与白细胞介素-2(IL-2)合用,提高IL-2效价两倍,C_(57)小鼠、正常人、肿瘤患者反应相似,依次略减。
A certain concentration of Asparagus officinalis Linn had obvious effects on the ex vivo cells of mouse lung adenocarcinoma (LA-795), human nasopharyngeal carcinoma (CNE), human cervical carcinoma (HeLa) and human esophageal carcinoma (Eca109) Cytotoxicity. The degree of killing of clonogenic cells was positively correlated with asparagus juice concentration and contact time. LA-795 cells were most sensitive (D_o = 1.3%), followed by CNE and HeLa cells (D_o = 2.1% and 2.6%). Eca109 cells were less sensitive (D_o = 4.4%). Asparagus extract on LA-739 mouse lung adenocarcinoma solid tumor growth inhibitory effect. Tumor volume measurements showed that asparagus extract delayed the average doubling time of tumors by four days, and the anti-tumor efficacy was about 1.5. Low concentration of asparagus juice (1.0% -0.1%) can promote the transformation and proliferation of peripheral blood T lymphocytes, which is a biological regulator of immune function. In combination with interleukin-2 (IL-2), the titer of IL-2 was increased by twice. The response of C57 mice, normal persons and tumor patients was similar, followed by a slight decrease.