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目的探讨血浆脂联素(APN)水平对男性高血压病(HBP)合并冠心病(CHD)患者冠脉粥样斑块稳定性的预测价值。方法入选80例因胸闷痛入院行冠脉造影术的男性HBP患者,按临床诊断分组,20例单纯HBP患者,HBP合并ACS患者38例,合并AMI患者20例,合并UAP患者18例;合并SAP患者22例。检测各受试对象的血浆APN水平。结果 HBP合并CHD组的血浆APN水平明显低于单纯HBP组(P﹤0.05);HBP合并ACS组血浆APN水平与HBP合并SAP组比较显著降低(P﹤0.05);HBP合并AMI组血浆APN水平低于HBP合并UAP组,但差异无统计学意义(P﹥0.05)。结论血浆APN水平与男性HBP合并CHD患者冠脉斑块稳定性显著相关,有助于临床预测此类患者冠脉斑块不稳定性。
Objective To investigate the predictive value of plasma adiponectin (APN) on the stability of coronary atherosclerotic plaques in male patients with hypertension (HBP) and coronary heart disease (CHD). Methods Eighty male patients with HBP who underwent coronary angiography due to chest pain were enrolled in this study. According to clinical diagnosis, 20 patients with HBP, 38 patients with HBP and ACS, 20 patients with AMI, 18 patients with UAP and SAP Twenty-two patients. Plasma APN levels were measured in each subject. Results Plasma APN level in HBP combined CHD group was significantly lower than that in HBP alone group (P <0.05). Plasma APN level in HBP combined with ACS group was significantly lower than that in HBP combined SAP group (P <0.05) UAP group was combined with HBP, but the difference was not statistically significant (P> 0.05). Conclusions Plasma APN level is significantly correlated with coronary plaque stability in male patients with HBP and CHD, which is helpful for the clinical prediction of coronary plaque instability.