目的 :探讨一氧化氮 (NO)、内皮素 - 1(ET- 1)、前列环素 (PGI2 )、血栓素 A(TXA2 )、降钙素基因相关肽(c GRP)多种血管活性物质对妊高征发病的影响。方法 :应用放射免疫法测定 6 0例妊高征患者 ,2 3例正常妊娠妇女血浆ET- 1、PGI2 、TXA2 、c GRP浓度 ,用 Griess法测定 NO浓度。结果 :1妊高征患者血浆 NO、PGI2 、c GRP浓度降低 ,NO与妊高征病情呈负相关 ,PGI2 、c GRP与中、重度妊高征病情呈负相关。 2妊高征患者血浆 ET- 1、TXA2 浓度增高 ,ET- 1与妊高征病情呈正相关。,TXA2 与中、重度妊高征病情呈正相关。 3上述 5种血管活性物质相关分析 ,NO与 ET- 1、TXA2 与中、重度妊高征呈负相关 ,NO与 PGI2 、c GRP呈正相关 ,ET- 1与 PGI2 、c GRP呈负相关。结论 :1NO、ET- 1、PGI2 、TXA2 、c GRP可做为判断妊高征病情的指标。 2多种血管活性物质在妊高征发病中具有协同和拮抗作用。 3妊高征的病因发病机制可能为多途径所致 Objective: To investigate the effects of nitric oxide (NO), endothelin - 1 (ET - 1), prostacyclin (PGI2), thromboxane A (TXA2) and calcitonin gene related peptide The impact of pregnancy-induced hypertension syndrome. Methods: Plasma levels of ET-1, PGI2, TXA2 and c GRP in 60 PIH patients and 23 normal pregnant women were measured by radioimmunoassay. The concentration of NO was determined by Griess method. Results: The levels of NO, PGI2 and cGRP in plasma of patients with PIH were decreased, NO was negatively correlated with PIH, and PGI2 and GRP were negatively correlated with those with moderate and severe PIH. 2 PIH plasma ET-1, TXA2 concentrations increased, ET-1 and pregnancy-induced hypertension were positively correlated. , TXA2 and moderate and severe pregnancy-induced hypertension were positively correlated. There was a negative correlation between NO, ET-1, TXA2 and moderate and severe pregnancy-induced hypertension syndrome. NO was positively correlated with PGI2, c GRP, ET-1 was negatively correlated with PGI2, c GRP.3. Conclusion: 1NO, ET-1, PGI2, TXA2, c GRP can be used as indicators to determine the status of PIH. 2 A variety of vasoactive substances have synergistic and antagonistic effects in the pathogenesis of PIH. The pathogenesis of PIH may be caused by many ways