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[目的]探讨戊肝患者及其密切接触者血清抗体的携带现状以及HEV与HBV重叠感染状况。[方法]用酶联免疫吸附试验(ELISA)法对94例戊肝患者及其密切接触者人群血清标本开展抗HAV-IgM、HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc、抗-HCV、抗HEV-IgM、抗HEV-IgG检测,对两组研究对象实验室检测结果用χ2检验进行统计分析。[结果]病例组抗HEV-IgM和抗HEV-IgG阳性率分别为27.66%和89.36%,密切接触者组抗HEV-IgM和抗HEV-IgG阳性率分别为4.94%和64.20%,两组人群抗HEV-IgM和抗HEV-IgG阳性率差异有统计学意义(P﹤0.01)。病例组与密切接触者组伴HBV感染率分别为34.04%和30.86%,差异无统计学意义(χ2=0.20,P=0.65)。[结论]戊肝密切接触者有较高的抗HEV-IgM和抗HEV-IgG阳性率,戊肝患者与密切接触者人群相比未显示出较高的HBV感染率。
[Objective] To investigate the status of serum antibodies in patients with hepatitis E and their close contacts and the status of overlap infection of HEV and HBV. [Methods] Serum samples of 94 patients with hepatitis E and their close contacts were detected by enzyme linked immunosorbent assay (ELISA) against HAV-IgM, HBsAg, anti-HBs, -HCV, anti-HEV-IgM and anti-HEV-IgG, and the results of laboratory tests of two groups of subjects were statistically analyzed by χ2 test. [Results] The positive rates of anti-HEV-IgM and anti-HEV-IgG in cases were 27.66% and 89.36% respectively. The positive rates of HEV-IgM and anti-HEV-IgG in close contacts were 4.94% and 64.20% respectively. The positive rates of anti-HEV-IgM and anti-HEV-IgG were statistically significant (P <0.01). The infection rates of HBV in case group and close contact group were 34.04% and 30.86%, respectively, with no significant difference (χ2 = 0.20, P = 0.65). [Conclusion] The close contacts of Hepatitis E have a higher positive rate of anti-HEV-IgM and anti-HEV-IgG, and Hepatitis E patients do not show higher HBV infection rate than the close contacts.