反流纠正术可防止膀胱输尿管返流和梗阻性尿路病变的进行性肾功能恶化,然而最近报告指出,一旦发生肾功能不全则此术就不能阻止肾功能的恶化。作者报告5例膀胱输尿管返流有肾功能不全者,输尿管再植术成功后,反流完全纠正,感染获根治,但仍有持续大量蛋白尿,并进行性发展为肾功能衰竭而必需作长期的血液透析或肾移植。膀胱输尿管返流引起的肾功能损伤由感染或返流的机械性影响所致。返流可引起感染,感染也被视为返流的原因,两者均可使肾功能迅速恶化.返流性肾脏病的病变多为慢性肾盂肾炎或慢性萎缩性肾盂肾炎,但近有报道其组织学除间质性病变外尚有肾小球 Reflux correction prevents progression of vesicoureteral reflux and progressive renal dysfunction in obstructive urothelial lesions, but recent reports indicate that this procedure does not prevent the deterioration of renal function in the event of renal insufficiency. The authors report 5 cases of vesicoureteral reflux with renal insufficiency, ureter replantation was successful, the reflux was completely corrected, the infection was cured, but there are still large amounts of proteinuria and progressive development of renal failure and the need for long-term Hemodialysis or kidney transplant. Renal impairment caused by vesicoureteral reflux is caused by the mechanical effects of infection or regurgitation. Recurrence can cause infection, infection is also considered the cause of reflux, both of which can make the rapid deterioration of renal function .Retorenal nephropathy lesions are mostly chronic pyelonephritis or chronic atrophic pyelonephritis, but it has been reported Histology in addition to interstitial lesions have glomeruli