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目的探讨LEEP刀联合人重组干扰素α2b阴道泡腾片对宫颈柱状上皮异位的治疗效果并探讨相关机制。方法将62例宫颈柱状上皮异位患者按照随机数表法平均分为对照组及治疗组,均接受LEEP刀治疗,治疗组在LEEP刀治疗基础上应用人重组干扰素α2b阴道泡腾片进行联合治疗。观察并比较两组患者治疗总有效率及治疗前后宫颈人乳头瘤病毒(HPV)、单纯疱疹病毒(HSV)以及巨细胞病毒(HCMV)病毒RNA水平及患者病毒转阴率。结果治疗组临床治疗总有效率为90.32%,显著高于对照组的80.65%,两组比较,差异有统计学意义(χ2=4.554,P<0.05);治疗组患者病毒HPV、HSV以及HCMV转阴率均显著高于对照组,两组比较,差异有统计学意义(P<0.05);治疗后治疗组患者HPV、HSV及HCMV的RNA水平均显著低于对照组,两组比较,差异有统计学意义(P<0.05)。结论 LEEP刀联合人重组干扰素α2b阴道泡腾片治疗宫颈柱状上皮异位疗效显著,值得临床推广应用。
Objective To investigate the therapeutic effect of LEEP knife combined with recombinant interferon α2b vaginal effervescent tablet on cervical columnar epithelial ectopic and explore the related mechanism. Methods 62 cases of cervical columnar epithelial ectopic patients according to the random number table were equally divided into control group and treatment group, were treated with LEEP knife, the treatment group in the LEEP knife treatment based on human recombinant interferon α2b vaginal effervescent tablets were combined treatment. To observe and compare the total effective rate of the two groups of patients before and after treatment of cervical HPV and herpes simplex virus (HSV) and cytomegalovirus (HCMV) virus RNA levels and patients with viral negative rate. Results The total effective rate of clinical treatment in the treatment group was 90.32%, which was significantly higher than that in the control group (80.65%). There was significant difference between the two groups (χ2 = 4.554, P <0.05). HPV, HSV and HCMV (P <0.05). After treatment, the RNA levels of HPV, HSV and HCMV in the treatment group were significantly lower than those in the control group, the differences between the two groups were statistically significant Statistical significance (P <0.05). Conclusions LEEP knife combined with recombinant interferon α2b vaginal effervescent tablets treatment of cervical columnar epithelial heterotopic significant effect, worthy of clinical application.