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为研究螺旋藻对实验性矽肺大鼠体内抗氧化水平的作用，实验设空白对照组、染尘对照组和染尘螺旋藻实验组，用非暴露式气管注入法复制大鼠矽肺模型，饲养１２周。结果表明：螺旋藻能显著提高染尘大鼠超氧化物歧化酶和谷胱甘肽过氧化物酶抗氧化酶的活性，降低肺组织中丙二醛的含量和支气管肺泡灌洗液中乳酸脱氢酶、酸性磷酸酶的含量。结果提示：（１）螺旋藻具有提高实验性矽肺大鼠体内抗氧化水平的作用；（２）螺旋藻在一定程度上能延缓或抑制矽肺病变的发展；（３）螺旋藻提高机体抗氧化水平的作用机理可能与其含有的微量元素Ｓｅ和β胡萝卜素等营养成分有关。
In order to study the effect of Spirulina platensis on the anti-oxidation of experimental silicosis rats, the blank control group, the control group of dyed dust and the experimental group of Dust-exposed Spirulina were set up. The non-exposed tracheal injection method was used to replicate the rat silicosis model. week. The results showed that Spirulina could significantly increase the activity of superoxide dismutase and glutathione peroxidase anti-oxidase in the infected rats, decrease the content of malondialdehyde in lung tissue and the concentration of lactate in bronchoalveolar lavage fluid Hydrogenase, acid phosphatase content. The results suggest that: (1) Spirulina platensis can improve the anti-oxidation level in experimental silicosis rats; (2) Spirulina can delay or inhibit the development of silicosis to a certain degree; (3) The mechanism of action may be related to its contained trace elements Se and β-carotene and other nutrients.