论文部分内容阅读
为研究小鼠肝脏中是否存在MCLR受体 ,通过I12 5标记MCLR示踪 ,分析小鼠各脏器中MCLR的特异性分布 ,以及根据受体识别标准研究小鼠肝脏匀浆中MCLR的特异性结合组分。结果表明 ,MCLR在小鼠脏器中存在差别性分布 ,与肝脏匀浆中结合因子的结合符合受体特征 ;结论 :小鼠肝脏中存在MCLR受体 ,提示MCLR的新的毒理途径
To investigate the presence of MCLR receptors in the liver of mice, the MCLR traces were traced by I 152 markers to analyze the specific distribution of MCLR in various organs of mice, and the specificity of MCLR in mouse liver homogenates was studied according to receptor recognition criteria. Combined components. The results showed that there was a differential distribution of MCLR in mouse organs, and the binding of binding factors in liver homogenate was consistent with receptor characteristics. Conclusion: MCLR receptors are present in mouse liver, suggesting a new toxicological mechanism of MCLR.