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目的：为探索有效合理的综合治疗腹部外科危重症的方法，提出“四大一支持”综合疗法，并应用于临床，观察其疗效。方法：采用“四大一支持”综合疗法①短程大剂量山莨菪碱；②短程大剂量地塞米松；③大剂量抗需氧菌和抗厌氧菌抗生素联合正确应用；④大剂量应用腹腔灌洗液清洗腹腔；⑤一支持即完全的代谢营养支持。结果：75例危重外科病人并发多器官功能障碍24例，死亡10例，治愈65例。结论：“四大一支持”综合冲击疗法具有显著地改善微循环、抗细胞因子、抗氧自由基及促进损伤细胞逆转的作用。该方法对危重患者有扼止危重状态进展，促进症状缓解，改善微循环及良好的降温、抗毒、抗炎、抗休克作用，对重要脏器无损伤作用。
Objective: To explore an effective and comprehensive method of comprehensive treatment of critically ill abdominal surgery, put forward “four big one support” comprehensive therapy, and applied to clinical observation of its efficacy. Methods: The “four big one support” comprehensive therapy ① short-range high-dose anisodamine; ② short-term high-dose dexamethasone; ③ large doses of anti-aerobic and anti-anaerobic antibiotics combined with the correct application; ④ large doses of peritoneal lavage fluid cleaning Abdominal; ⑤ a support that is completely metabolic nutrition support. Results: Seventy-five cases of critically ill surgical patients complicated with multiple organ dysfunction were diagnosed as 24 cases, 10 died and 65 cases were cured. Conclusion: “Four in One Support” comprehensive impact therapy can significantly improve the microcirculation, anti-cytokines, antioxidant free radicals and promote the reversal of injured cells. The method for critically ill patients with critical state of progress, promote symptoms, improve microcirculation and good cooling, anti-virus, anti-inflammatory, anti-shock, no damage to vital organs.