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目的 探讨孕、乳期补充富含DHA鱼油对大鼠行为发育的影响。方法 以出生前、后脑发育关键期大鼠为研究对象,设1个对照组和添加鱼油的3个剂量组(其中DHA的量分别为0、7.5、15.0、30.0g/kg饲料),喂养期限为孕0日至仔鼠45日龄。观察妊娠、分娩一般指标,进行断乳前行为发育评价、幼鼠学习行为测试等。结果 与对照组相比,DHA 15.0g/kg饲料组新生鼠脑重显著增加(P<0.05);2项新生反射指标平面翻正、视觉定向发育显著提前(P<0.05);跳台潜伏期延长,错误次数减少和避暗潜伏期延长(P<0.05)。结论 孕、乳期补充一定剂量的DHA,可对子代大鼠神经发育产生有益影响;孕、乳期补充DHA的较适剂量为15.0g/kg饲料。
Objective To investigate the effects of pregnant and lactating phase enriched DHA fish oil on behavioral development in rats. Methods The rats in the critical stage of prenatal and postnatal brain development were divided into three groups: control group and fish oil supplemented with 3 doses of DHA (0, 7.5, 15.0, 30.0 g / kg, respectively), feeding period For pregnant 0 to pups 45 days old. Observe the general indicators of pregnancy, childbirth, pre-weaning behavior development assessment, pupils learning behavior test. Results Compared with the control group, the brain weights of neonatal rats in DHA 15.0g / kg group were significantly increased (P <0.05); the indexes of two neonatal reflex planes were reversed and the visual orientation was significantly advanced (P <0.05) Reduce the number of errors and avoid dark latency (P <0.05). Conclusion Supplementation of DHA at pregnant and lactational stages can have beneficial effects on the neurodevelopment of offspring rats. The suitable dosage of DHA supplementation during pregnancy and lactation is 15.0g / kg diet.