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铁蛋白(Ferritin)是一种分子量较大的含铁蛋白质,是铁的主要贮存形式之一。人体内几乎所有的细胞都含有铁蛋白,血清、脑脊液及尿液中也含有铁蛋白。自从1972年Addison等建立了血清铁蛋白放免测定法后,不少学者探讨了铁蛋白含量在急性白血病中的临床意义,本文就此综述如下。一.血清铁蛋白健康成年男性血清铁蛋白(SF)的范围为20～330μg/L,女性为9～200μg/L,儿童为7～142μg/L。1973年Jones等首次报道了治疗前的急性白血病(AL)患者SF显著增高,35例急粒患者SF均值为589μg/L(155～2 200μg/L),为正常对照组的10倍。其后许多报道均表明,治疗前的成人及儿童AL患者SF
Ferritin is a high molecular weight iron-containing protein that is one of the major forms of storage of iron. Almost all human cells contain ferritin, serum, cerebrospinal fluid and urine also contains ferritin. Since 1972, Addison and other established serum ferritin radioimmunoassay, many scholars discussed the clinical significance of ferritin content in acute leukemia, this article is summarized below. Serum Ferritin Healthy adult male serum ferritin (SF) ranged from 20 to 330 μg / L for women and 9 to 200 μg / L for women and 7 to 142 μg / L for children. In 1973, Jones et al. First reported SF in patients with acute leukemia (AL) before treatment was significantly higher than that in the control group. The average SF of 35 patients with acute myeloma was 589 μg / L (155-2 200 μg / L), which was 10 times of that in the normal control group. Subsequent reports have shown SF in adult and childhood AL patients before treatment