酮洛酸(Ketolorac)(以下简称K)是一种非麻醉性镇痛药,具有解热、镇痛、抗炎作用。作者比较K和吗啡的镇痛效果和安全性。受试者为155例中至重度疼痛病人,受试前1～2天均接受腹部外科或矫形外科手术,排除孕妇和授乳期妇女。试验按双盲、随机方式给予单剂K 10、30和90mg或吗啡6和12mg肌注,在给药后的6小时内按一定时间间隔记录受试者的主观和客观疼痛程度以及止痛作用评分。结果:K 90和30mg的止痛作用,在给药后1小时均显著优于吗啡6 mg;给药后3小时等于吗啡12 mg;给药后4小时优于吗啡12mg。副作用均很轻微, Ketolorac (hereinafter referred to as K) is a non-narcotic analgesic with antipyretic, analgesic and anti-inflammatory effects. The authors compared the analgesic effect and safety of K and morphine. Subjects were 155 patients with moderate to severe pain, abdominal surgery or orthopedic surgery 1 to 2 days before the test, excluding pregnant women and lactating women. Tests were given in double-blind, randomized, single doses of K 10, 30, and 90 mg or morphine 6 and 12 mg intramuscularly, subjectively and objectively painful, and analgesic scores were recorded at regular time intervals within 6 hours of administration . RESULTS: The analgesic effects of K 90 and 30 mg were significantly better than morphine 6 mg 1 h after dosing, 12 mg 3 h after morphine, and 12 mg 4 h after morphine dosing. Side effects are mild,