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本文用离子对反相高效液相色谱法检测了32例肺癌患者及11例肺良性疾患患者术前、术后近期及45例正常人尿Ψ(即假尿核苷,Pseudouridine)水平,以探讨其在肺癌患者中的应用价值。结果表明:肺癌患者尿Ψ水平明显高于正常人及肺良性疾患患者,差异有显著意义(P<0.05);经根治手术及经化疗达CR的患者术后尿Ψ水平较术前明显下降,可至正常水平,差异有显著意义(P<0.05);行非根治性手术及化疗疗效非达CR者,无明显变化,差异无显著性(P>0.05);肺癌患者术前尿Ψ水平与临床病理分期及组织类型无明显关系,差异无显著性。本文认为,检测尿Ψ水平在肺癌的诊断、评价疗效及估计预后方面具有一定的应用价值。
In this paper, 32 patients with lung cancer and 11 patients with benign lung disease were examined by ion-pair reversed-phase high-performance liquid chromatography before and after surgery, and 45 patients with normal urine (Pseudouridine) levels were studied. Its application value in lung cancer patients. The results showed that the level of urinary excretion in lung cancer patients was significantly higher than that in normal and benign lung patients, with significant differences (P<0.05). The postoperative urinary fistula levels in patients undergoing radical surgery and CR after chemotherapy were significantly lower than those before surgery. The difference was statistically significant (P<0.05). There was no significant difference in non-radical surgery and non-CR treatment efficacy (P>0.05); the preoperative urinary fistula level in patients with lung cancer was not significantly different (P>0.05). There was no significant relationship between clinical pathological stage and tissue type, and the difference was not significant. This article believes that the detection of urinary level has a certain application value in the diagnosis, evaluation of curative effect and estimation of prognosis of lung cancer.