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目的：康赛德止痛汤在临床初试中镇痛效果明显，为进一步验证其镇痛效果，进行本实验。方法：采用镇痛实验经典方法热板法及扭体法进行实验。结果：热板法结果表明：①康赛德止痛汤能明显提高小白鼠痛阈值，与生理盐水组或用药前后自身对比均显示差异有统计学显著性意义（Ｐ＜０．０１）；②痛阈的提高与剂量呈正相关趋势。扭体法结果表明：①康赛德止痛汤能明显减少扭体反应鼠数，与生理盐水组比较，差异有统计学显著性意义（Ｐ＜０．０１）；②镇痛率的提高随着剂量的增加而增加，呈量效关系。结论：康赛德止痛汤是一个具有较强镇痛作用的方药，且随着剂量的增加，镇痛率相应增加，呈现明显的量效关系
OBJECTIVE: The analgesic effect of Kangsaide Zhitong Decoction in the initial clinical trial is obvious. To further verify its analgesic effect, this experiment was performed. Methods: Experiments were performed using the hot plate method and the writhing method. RESULTS: The results of hot plate method showed that Kangxiande Zhitong Decoction could significantly increase the pain threshold of rats, and there was significant difference between the two groups (P<0.01); The increase in the threshold is positively correlated with the dose. The results of writhing showed that: Kangxiande Zhitongtang can significantly reduce the number of writhing rats, compared with the saline group, the difference was statistically significant (P <0.01); 2 the improvement of the analgesic rate The dose increased and showed a dose-effect relationship. Conclusion: Kangsaide Zhitong Decoction is a prescription with strong analgesic effect. With the increase of dose, the analgesic rate increases accordingly, showing a clear dose-effect relationship.