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目的探讨从正常肝脏到肝炎后肝硬化的演变过程中,相关脏器的时间-密度曲线(TDC)变化规律。资料与方法3组共120例(正常对照组34例,肝炎肝纤维化组48例,肝炎后肝硬化组38例)经CT同层动态增强扫描得到腹主动脉、门静脉、肝实质、脾脏实质等4个感兴趣区(ROI)TDC,分析3组ROI达峰时间(TTP)和峰值高度(PV)。结果3组主动脉的TTP无差异性,PV有统计学差异;3组门静脉、肝脏、脾的TTP及PV均有统计学意义,均为TTP渐延长,PV渐下降。结论门静脉、肝脏、脾等相关脏器的TDC表现反映了肝炎后肝硬化的血流动力学变化。
Objective To investigate the change of time-density curve (TDC) of the related organs during the development of liver cirrhosis from normal liver to hepatitis. Materials and Methods A total of 120 patients in 3 groups (control group, 34 cases, 48 cases of liver fibrosis group and 38 cases of posthepatitis cirrhosis group) were obtained by dynamic contrast-enhanced CT scan of abdominal aorta, portal vein, liver parenchyma, Four areas of interest (ROI), such as TDC, were used to analyze the peak time (TTP) and peak height (PV) of ROI. Results There was no difference in TTP among the three groups of aorta and the PV was statistically different. The TTP and PV of the portal vein, liver and spleen in the three groups were all statistically significant, both of which were prolonged TTP and decreased gradually. Conclusion The TDC findings of portal organs, liver, spleen and other related organs reflect the hemodynamic changes of posthepatitic cirrhosis.