论文部分内容阅读
用~（４５）Ｃａ跨膜流动测定方法研究地奥心血康及维拉帕米对大鼠主动脉Ｃａ~（２＋）跨膜内流的影响。结果：地奥心血康５－５００μｇ／ｍＬ和维拉帕米０．０１１－１．１μｍｏｌ／Ｌ，不影响静息~（４５）Ｃａ的内流，但均能浓度依赖性抑制去甲肾上腺素１．２ｍｏｌ／Ｌ和ＫＣｌ１００ｍｍｏｌ／Ｌ引起的~（４５）Ｃａ内流。说明地奥心血康能阻滞细胞外Ｃａ~（２＋）通过受体操纵与电压依赖钙离子通道的内流。
The effect of diaoxinxuekang and verapamil on Ca~(2+) transmembrane influx in rat aorta was studied by ~(45)Ca transmembrane flow assay. Results: Dioxin Xuekang 5-500μg/mL and verapamil 0.011-1.1μmol/L, did not affect the inflow of resting 45Ca, but it could inhibit the concentration of norepinephrine 1.2mol in a concentration-dependent manner. Influx of ~(45)Ca caused by /L and KCl 100 mmol/L. It shows that Dioxin blood can block extracellular Ca~(2+) through receptor manipulation and the influx of voltage-dependent calcium channels.