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目的探讨儿童社区获得性肺炎应用阿莫西林克拉维酸钾与阿奇霉素联合治疗的疗效和安全性。方法 94例社区获得性肺炎患儿,根据收治顺序单双号分为观察组和对照组,每组47例。对照组采用阿莫西林克拉维酸钾治疗,观察组采用阿莫西林克拉维酸钾与阿奇霉素联合治疗,治疗时间均为14 d。观察并比较两组治疗效果、住院时间和不良反应。结果观察组治疗总有效率为93.62%,高于对照组的80.85%,差异有统计学意义(χ~2=9.287,P<0.05);观察组住院时间为(8.93±2.01)d,短于对照组的(11.56±2.16)d,差异有统计学意义(t=-6.111,P<0.05);观察组不良反应发生率为6.38%,对照组为8.51%,两组比较差异无统计学意义(χ~2=0.154,P>0.05)。结论儿童社区获得性肺炎应用阿莫西林克拉维酸钾与阿奇霉素联合治疗的疗效优于单纯阿莫西林克拉维酸钾治疗,且可以显著缩短住院时间,安全性良好,值得临床积极推广应用。
Objective To investigate the efficacy and safety of amoxicillin and clavulanate combined with azithromycin in children with community-acquired pneumonia. Methods A total of 94 children with community-acquired pneumonia were divided into observation group and control group according to the sequence of admission and treatment, with 47 cases in each group. The control group was treated with amoxicillin and clavulanate potassium. The observation group was treated with amoxicillin and clavulanate combined with azithromycin for 14 days. Observed and compared the two groups of treatment, hospital stay and adverse reactions. Results The total effective rate in the observation group was 93.62%, which was higher than that in the control group (80.85%), the difference was statistically significant (χ ~ 2 = 9.287, P <0.05). The length of stay in the observation group was (8.93 ± 2.01) The difference was statistically significant (t = -6.111, P <0.05) in the control group (11.56 ± 2.16) d, the incidence of adverse reactions in the observation group was 6.38% and that in the control group was 8.51%, there was no significant difference between the two groups (χ ~ 2 = 0.154, P> 0.05). Conclusions The efficacy of amoxicillin and clavulanate combined with azithromycin in children with community-acquired pneumonia is better than that of amoxicillin and clavulanate alone. It can shorten the length of hospital stay and have good safety. It is worthy of clinical promotion and application.