α－氨基膦酸及其酯与α－氨基酸结构类似，其具有抑菌［１］、抗肿瘤［２］、杀虫［３］以及抗植物病毒［４～７］的活性．α－氨基膦酸酯上与磷原子相连的２个烷氧基不同、α位碳原子以及氨基上取代基的不同将导致生物活性的巨大差异［８］．吡唑是一具有多种生物活性的... α-Aminophosphonic acids and their esters are structurally similar to those of α-amino acids and have antibacterial activities [1], antitumor activity [2], insecticidal activity [3] and anti-plant viruses [4-7]. α-Aminophosphonates and phosphorus atoms connected to the two different alkoxy, α-carbon atoms and amino substituents will result in a huge difference in biological activity [8]. Pyrazole is a variety of biological activity ...