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回顾性分析我科住院LADA患者临床资料,并与T2DM患者比较,分析两组间糖尿病症状、酮症发生率、血糖、BMI、胰岛β细胞功能、磺脲类药物服用情况及自身免疫性甲状腺疾病发病率等。结果与T2DM组比较,LADA多有糖尿病症状(P<0.05),体型偏瘦(P<0.01);血糖高(P<0.01),HbA1c高(P<0.05),酮症高发(P<0.01),FCP、2hCP明显降低(P<0.01;AITD发生率高(P<0.05);磺脲类药物服用情况普遍,与2型糖尿病组无差异(P>0.05)。结论 LADA患者体型偏瘦、糖尿病症状明显,酮症发生率高且程度较重,胰岛β细胞功能差,合并自身免疫性甲状腺疾病较多见,误诊率高,不规范诊疗普遍。
The clinical data of LADA patients in our department were retrospectively analyzed. Compared with T2DM patients, the symptoms of diabetes mellitus, incidence of ketosis, blood glucose, BMI, beta-cell function, sulfonylurea use and autoimmune thyroid disease Incidence and so on. Results Compared with T2DM group, LADA had more symptoms of diabetes mellitus (P <0.05), body size was lean (P <0.01), higher blood glucose (P <0.01), higher HbA1c (P < (P <0.01). The incidence of AITD was higher (P <0.05). The prevalence of sulfonylureas was generally lower than that of type 2 diabetes mellitus (P0.05) Symptoms are obvious, high incidence and severity of ketosis, pancreatic β-cell function is poor, more common with autoimmune thyroid disease, misdiagnosis rate, non-standard diagnosis and treatment are common.