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目的:研究Survivin基因在儿童急性淋巴细胞白血病(ALL)中的表达及意义。方法:RT-PCR法检测Sur-vivin基因表达。结果:Survivin基因表达:初发组和对照组、初发组和完全缓解组、复发组和对照组间比较均有统计学差异(P<0.05)。结论:Survivin基因与儿童ALL的发病机制有关。
Objective: To investigate the expression and significance of Survivin gene in childhood acute lymphoblastic leukemia (ALL). Methods: Survivin gene expression was detected by RT-PCR. Results: The expression of Survivin gene in primary group and control group was significantly higher than that in primary group and complete remission group (P <0.05). Conclusion: Survivin gene is associated with the pathogenesis of childhood ALL.