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目的观察血清降钙素原(PCT)检测在小儿肺炎中的应用。方法选取医院肺炎患儿84例为观察组,根据病情分为重症组(36例)和轻症组(48例),同时抽取同期84例健康体检者为对照组。观察患儿病原菌分布情况,肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)及血清PCT水平。结果 84例肺炎患儿检测出病原菌138株,其中革兰阳性菌59株(42.8%),革兰阴性菌79株(57.2%);革兰阳性菌与革兰阴性菌感染轻症组TNF-α、IL-8及PCT水平均低于重症组(P<0.05);革兰阳性菌重症组及革兰阴性菌重症组、轻症组PCT水平均高于对照组(P<0.05);革兰阴性菌感染重症组PCT水平高于革兰阳性菌感染重症组(P<0.05);革兰阳性菌感染轻症组PCT水平与对照组比较,差异无统计学意义(P>0.05)。结论对肺炎患儿血清PCT水平进行检测,有助于肺炎的鉴别诊断与病情评估,及时给予针对性治疗,避免抗生素滥用。
Objective To observe the application of serum procalcitonin (PCT) in children with pneumonia. Methods Eighty-four children with pneumonia in hospital were selected as the observation group. According to the condition, they were divided into severe group (36 cases) and mild group (48 cases). 84 healthy subjects were selected as the control group. The distribution of pathogenic bacteria in children, tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8) and serum PCT levels were observed. Results A total of 138 pathogens were detected in 84 children with pneumonia, of which 59 were Gram-positive bacteria (42.8%) and 79 were Gram-negative bacteria (57.2%). Gram-positive bacteria and gram- (P <0.05). The levels of PCT in severe Gram-positive bacteria and Gram-negative bacteria in severe and mild group were higher than those in control group (P <0.05); leather The level of PCT in patients with severe gram-negative bacteria infection was significantly higher than that in gram-positive bacteria patients (P <0.05). There was no significant difference in PCT between mild gram-positive bacteria and controls (P> 0.05). Conclusions The detection of serum PCT levels in children with pneumonia is helpful for the differential diagnosis and assessment of pneumonia. The targeted treatment should be timely given to avoid the abuse of antibiotics.