论文部分内容阅读
目的对比胃铋镁四联疗法与枸橼酸铋钾四联疗法治疗幽门螺杆菌(Hp)相关性消化性溃疡的疗效,并评价两者的安全性。方法选取2016年1月—2017年1月收治的Hp相关性消化性溃疡患者86例,通过数字表法随机分成观察组和对照组,各43例;对照组采用枸橼酸铋钾四联疗法(枸橼酸铋钾+泮托拉唑+阿莫西林+呋喃唑酮),观察组采用胃铋镁四联疗法(胃铋镁+泮托拉唑+阿莫西林+呋喃唑酮),均持续用药4周,对比分析两组治疗总有效率和Hp清除率。计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果治疗后,观察组总有效率、Hp清除率(95.3%、92.4%)均高于对照组(81.4%、78.8%),差异有统计意义(均P<0.05)。与治疗前比较,治疗后两组IL-6水平均降低,IL-10水平均升高,差异有统计学意义(均P<0.05);观察组治疗后IL-6水平(18.25±7.62)ng/m L低于对照组(25.96±8.02)ng/m L,IL-10水平(19.68±5.74)pg/m L高于对照组(14.95±4.07)pg/m L,差异具有统计学意义(P<0.05);两组均未出现明显不良反应。结论与枸橼酸铋钾四联疗法对比,胃铋镁四联疗法治疗Hp相关性消化性溃疡效果更确切,有助于改善症状,清除Hp,减少炎性浸润,促进愈合。
Objective To compare the curative effect of gastric bismuth-magnesium quadruple therapy and bismuth-potassium citrate quadruple therapy on peptic ulcer associated with Helicobacter pylori (Hp) and to evaluate the safety of the two. Methods Totally 86 patients with Hp-related peptic ulcer were enrolled from January 2016 to January 2017. They were randomly divided into observation group and control group by digital table method, 43 cases in each group. The control group was treated with bismuth potassium citrate quadruple therapy (Bismuth potassium citrate + pantoprazole + amoxicillin + furazolidone). The observation group was treated with gastric bismuth magnesium quadruple therapy (gastric bismuth magnesium + pantoprazole + amoxicillin + furazolidone) for 4 weeks , Comparative analysis of two groups of total effective rate and Hp clearance rate. Measurement data were compared using t test, count data were compared using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results After treatment, the total effective rate and the Hp clearance rate in the observation group (95.3%, 92.4%) were significantly higher than those in the control group (81.4%, 78.8%, respectively) (all P <0.05). Compared with those before treatment, the levels of IL-6 in both groups decreased and the levels of IL-10 increased after treatment (all P <0.05). The levels of IL-6 in the observation group after treatment were 18.25 ± 7.62 ng / m L was lower than that of control group (25.96 ± 8.02) ng / m L, IL-10 level (19.68 ± 5.74) pg / m L was significantly higher than that of control group (14.95 ± 4.07 pg / m L) P <0.05); no obvious adverse reaction was found in both groups. Conclusion Compared with bismuth potassium citrate quadruple therapy, gastric bismuth magnesium quadruple therapy is more effective in treating Hp-related peptic ulcer, which can help to improve symptoms, clear Hp, reduce inflammatory infiltration and promote healing.