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目的探讨中、晚期宫颈鳞癌在进行放化疗治疗后复发未控的相关影响因素,以提高放化疗的治疗效果。方法将收治的170例中、晚期宫颈鳞癌患者的病历资料进行回顾性分析,其中未控制及3个月后复发者共计36例(复发组),控制良好及3个月后未复发者134例(控制组),比较两组在肿瘤的临床分期、细胞分化程度、癌灶大小、淋巴结转移、治疗前血红蛋白(Hb)水平、放疗时间、放疗剂量及化疗疗程之间的统计学差异,以分析其与复发、未控的关系。结果未控组与控制组在肿瘤分化程度、癌灶大小、淋巴结转移情况、治疗前Hb水平、放疗时间、化疗时间等方面有明显差异(P<0.05),与放疗剂量无明显差异(P>0.05)。结论癌肿直径大、分化程度低、有淋巴结浸润、Hb水平低是患者放化疗后未控或复发的高危因素,同时化疗时间和放疗时间也对患者的复发有一定的影响。
Objective To investigate the influencing factors of uncontrollable recurrence of advanced squamous cell carcinoma of the cervix after radiotherapy and chemotherapy in order to improve the therapeutic effects of radiotherapy and chemotherapy. Methods A retrospective analysis was performed on the medical records of 170 patients with advanced cervical squamous cell carcinoma who were admitted to our hospital. Among them, 36 cases (control group) were uncontrolled and relapsed after 3 months, and were well controlled and had no relapse after 3 months (Control group). The differences between the two groups in the clinical staging, cell differentiation, tumor size, lymph node metastasis, pretreatment hemoglobin (Hb) level, radiotherapy time, radiotherapy dose and chemotherapy regimen were compared Analysis of its relationship with recurrence, uncontrolled. Results There were significant differences in tumor differentiation, tumor size, lymph node metastasis, pre-treatment Hb level, radiotherapy time and chemotherapy time between the control group and the control group (P <0.05), but no significant difference was found between the control group and the control group (P> 0.05). Conclusions The large diameter, low degree of differentiation, lymph node infiltration and low Hb level are the risk factors of uncontrolled or recurrence of patients after radiotherapy and chemotherapy. Chemotherapy time and radiotherapy time also have certain influence on the recurrence of patients.