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目的观察珠蛋白生成障碍性贫血(地贫)高发区小儿地贫并缺铁性贫血(IDA)的临床特征。方法回顾性分析25例地贫并IDA的地贫突变类型和治疗效果。比较地贫并IDA组与单纯地贫组、单纯IDA组的血常规参数。结果 25例患儿中,轻型β-地贫14例,轻型α-地贫7例,中间型α-地贫3例,中间型β地贫1例。补铁治疗有效,血红蛋白升高(21.24±7.62)g.L-1。单纯地贫组红细胞容积、红细胞分布宽度和血小板计数较地贫并IDA组与单纯IDA组稍高(P<0.05),2组平均血红蛋白水平无明显差异(P>0.05)。结论在地贫高发区地贫患儿并IDA较常见,对地贫患儿需进行常规铁代谢指标测定。
Objective To observe the clinical features of thalassemia and iron deficiency anemia (IDA) in high incidence area of thalassemia. Methods A retrospective analysis of 25 cases of thalassemia and IDA thalassemia mutation type and treatment effect. Comparison of anemia with IDA group and simple poor group, simple IDA group of blood parameters. Results Of the 25 children, 14 cases were mild β-thalassemia, 7 cases were mild α-thalassemia, 3 cases were intermediate α-thalassemia and 1 case was intermediate β thalassemia. Iron therapy is effective, hemoglobin increased (21.24 ± 7.62) g.L-1. Compared with IDA group and IDA group, the volume of erythrocyte, erythrocyte distribution width and platelet count in thalassemia group were slightly higher than those in IDA group (P <0.05). There was no significant difference in average hemoglobin level between two groups (P> 0.05). Conclusions IDA is more common in children with thalassemia major thalassemia, and children with thalassemia need regular iron metabolism.