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目的探讨不同时期糖尿病慢性肾脏疾病(CKD)患者血清可溶性CD40配体(sCD40L)水平变化。方法根据UAER将93例T2DM患者分为正常白蛋白尿(NA)组38例,微量白蛋白尿(MA)组29例和临床白蛋白尿(CP)组26例,另选健康体检者25名为NC组。采用酶联免疫吸附法(ELISA)测定各组血清sCD40L水平。结果 T2DM患者血清sCD40L水平较NC组升高,且随UAER升高而升高。sCD40L水平与病程、HbA1c、TC呈正相关,与HDL-C、ApoA呈负相关。sCD40L、LDL-C、SBP为CKD的独立危险因素。结论 CKD患者血清CD40L水平升高,是T2DM并发CKD的独立相关因素。
Objective To investigate the changes of serum soluble CD40 ligand (sCD40L) in patients with chronic kidney disease (CKD) at different stages. Methods According to UAER, 93 patients with T2DM were divided into three groups: normal albuminuria (NA) group (38 cases), microalbuminuria group (MA) and clinical albuminuria group (26 cases) For the NC group. Serum sCD40L levels were measured by enzyme-linked immunosorbent assay (ELISA). Results The level of sCD40L in T2DM patients was higher than that in NC group and increased with the increase of UAER. The level of sCD40L was positively correlated with the course of disease, HbA1c and TC, but negatively correlated with HDL-C and ApoA. sCD40L, LDL-C, SBP are independent risk factors for CKD. Conclusion The serum level of CD40L in patients with CKD is an independent factor related to CKD in patients with T2DM.