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为了明确外源性透明质酸(HA)对实验性伤口愈合的作用,作者研究仓鼠颊袋伤口的愈合过程。实验采用雌性叙利亚金仓鼠(100～140g),在仓鼠右颊袋上用活检打孔器打一直径2mm小孔,实验是在腹腔内注射戊巴比妥钠9mg/100g麻醉下进行的。将1.5×8cm明胶海绵卷成小丸,用1.5ml水或HA溶液(16ms/dl)浸湿后,塞在仓鼠颊袋内,药丸通常在60～90分钟被仓鼠排出。在术后第1、3、5、7日重塞药丸。实验时气管插管给氧,直肠温度用电热毯保持在36～38℃。股动静脉内分别插入导管。在股
To clarify the effect of exogenous hyaluronic acid (HA) on experimental wound healing, the authors studied the healing process of hamster cheek pouch wounds. Female Syrian gold hamsters (100-140g) were used in the experiments. A diameter of 2mm holes were punched in the right cheek pocket of hamsters with a biopsy punch. The experiment was performed under the anesthesia of intraperitoneal injection of sodium pentobarbital 9mg / 100g. The 1.5 x 8 cm gelatin sponge was rolled into pellets and wetted with 1.5 ml of water or HA solution (16 ms / dl) and stuffed in the hamburger buccal pouch. The pellets were usually excreted by hamsters for 60-90 minutes. After the first 1, 3, 5, 7 resuscitation pills. Tracheal intubation experiment oxygen, rectal temperature with electric blanket maintained at 36 ~ 38 ℃. Femoral artery and vein were inserted into the catheter. In the stock