六种氟喹诺酮类药 (司帕沙星、妥舒沙星、环丙沙星、氧氟沙星、氟罗沙星及诺氟沙星 )对成都地区 780株临床分离的致病菌 ,其中革兰阳性菌 3 45株 ,革兰阴性菌 40 0株 ,厌氧菌 3 5株 ,进行体外抑菌试验 ,对其中体外抗菌作用强的三种药物进行感染小鼠败血症体内保护试验。体外MIC Six fluoroquinolones (sparfloxacin, tosufloxacin, ciprofloxacin, ofloxacin, fleroxacin and norfloxacin) in Chengdu area of ​​780 clinically isolated pathogens, including Gram 3 45 strains of positive bacteria, 40 0 ​​strains of Gram-negative bacteria and 35 strains of anaerobic bacteria. The antibacterial activity was tested in vitro. Three kinds of drugs with high antibacterial activity in vitro were tested for in vivo protection against sepsis in mice. In vitro MIC