消化系统恶性肿瘤发病率及死亡率均远远高于其他系统恶性肿瘤,因此,对消化系统恶性肿瘤的预防和治疗研究亟待进一步深入。目前,研究显示干预趋化因子/受体轴将影响实体肿瘤的生长和转移。本文旨在探讨趋化因子CXCL12及其受体CXCR4构成的生物轴与消化系统恶性肿瘤之间的关系,为 The morbidity and mortality of digestive system malignancies are much higher than those of other systemic malignancies. Therefore, the research on the prevention and treatment of digestive system malignant tumors needs further study. At present, studies show that intervention of chemokine / receptor axis will affect the growth and metastasis of solid tumors. This article aims to explore the relationship between the biological axis of the chemokine CXCL12 and its receptor CXCR4 and digestive system malignancies, as