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药物导致的急性间质肾炎(AIN),是双侧肾间质、肾小管非化脓性急性炎症为主要表现的综合征。随着抗生素等化学药物的广泛应用,其发生率日渐增多,约占急性肾衰(ARF)的8～20％,慢性肾衰的25％是AIN引起的。AIN已成为常见的肾脏病之一。AIN临床表现可以不典型,因而常有漏误诊或迁延成慢性间质肾炎,致使病者死于肾功能衰竭。提高对AIN的认识和诊治水平具有重要意义,现将AIN的研究进展综述如下:
Drug-induced acute interstitial nephritis (AIN) is a syndrome characterized mainly by bilateral renal interstitium, acute tubular non-suppurative inflammation. With the widespread use of antibiotics and other chemical drugs, its incidence is increasing, accounting for about 8 to 20% of acute renal failure (ARF), 25% of chronic renal failure is caused by AIN. AIN has become one of the common kidney diseases. AIN clinical manifestations can be atypical, which often misdiagnosed or delayed into chronic interstitial nephritis, resulting in the patient died of renal failure. AIN to improve awareness and diagnosis and treatment level is of great significance, now AIN research progress is summarized as follows: