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目的:单孔腹腔镜手术虽然取得了不错的临床效果，但其存在手术操作难度大、器械冲突、缺乏对抗牵引及直线视角等问题让很多外科医师望而却步。因此，有术者提出了单切口加一孔（SILS+1）的手术方法。本研究探讨运用SILS+1进行结直肠癌根治性切除术的安全性与可行性。方法:采用描述性病例系列研究的方法，回顾性收集从2018年3月至2019年1月在南方医科大学南方医院普通外科进行SILS+1治疗的178例结直肠癌患者的临床资料，分析患者手术情况、术后病理以及术后恢复情况（术后并发症分级采用Clavien-Dindo标准，疼痛指标为视觉模拟评分法）；通过门诊或电话进行随访，随访时间截至2019年5月。结果:共有178例患者接受了SILS+1结直肠癌根治性切除术，其中男性患者111例（62.4%）；平均年龄59岁。其中有11例（6.2%）患者中转加1~3个操作孔，1例（0.6%）患者因回结肠动脉出血中转开腹。全组患者手术时间为（135.2±42.3）min，术中失血量为（34.6±35.5）ml，淋巴结检出数目为（33.1±17.6）枚，远切缘（10.2±5.3）cm，近切缘（14.7±17.8）cm。术后30 d内16例（9.0%）出现手术相关并发症，其中6例为Clavien-Dindo Ⅲ级并发症（3.4%）；术后疼痛评分均低于3分。术后住院时间为（5.6±2.6）d。3例患者（1.7%）术后30 d内因肠梗阻和造口周围感染返院治疗。全组患者美容评分均为满意和基本满意。结论:SILS+1治疗结直肠癌具有较好的手术安全性和可行性，可减轻患者术后疼痛。“,”Objective:Although single port laparoscopic surgery has achieved good clinical results, many surgeons are discouraged by the difficulties of operation, conflict of instruments, lack of antagonistic traction, and straight-line perspective. Therefore, some surgeons have proposed a single incision plus one hole laparoscopic surgery (SILS+1) surgical method. This study explored the safety and feasibility of SILS+1 for radical resection of colorectal cancer.Methods:A descriptive cohort study was carried out. The clinical data, including the operation, pathology and recovery situation, of 178 patients with colorectal cancer undergoing SILS+1 at Department of General Surgery, Nanfang Hospital, Southern Medical University from March 2018 to January 2019 were prospectively collected and retrospectively analyzed. Clavien-Dindo criteria was used for postoperative complication evaluation and visual analog scale was used for pain standard. Follow-up studies were conducted through outpatient service or telephone and the follow-up period was up to May 2019.Results:A total of 178 patients with colorectal cancer underwent SILS+1, including 111 male patients (62.4%) with an average age of 59 years. Eleven (6.2%) patients received added 1-3 operation ports during operation, and 1 patient was converted to open surgery due to ileocolic artery hemorrhage. The operative time was (135.2±42.3) minutes. The intraoperative blood loss was (34.6±35.5) ml. The number of harvested lymph nodes was 33.1±17.6. The distal margin was (4.7±17.8) cm. The proximal margin was (10.2±5.3) cm. Operation-related complications were observed in 16 patients (9.0%) within 30 days after the operation, of whom 6 had Clavien-Dindo III complications (3.4%). The postoperative pain scores were lower than 3. The average postoperative hospital stay was (5.6±2.6) days. Three patients (1.7%) returned to hospital within 30 days after operation due to intestinal obstruction and infection around stoma. The cosmetic evaluation of all the patients was basically satisfied.Conclusion:SILS+1 is safe and feasible in the treatment of colorectal cancer, and can reduce the postoperative pain.