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我们按中国药典1977年版规定检查甘露醇的酸度、澄清度、草酸盐时,发现在实验条件上存在以下一些问题,并提出改进意见。一、酸度检查甘露醇原料酸度检查,按照中国药典方法是取本品5g,加新沸过的冷蒸馏水50ml 溶解后,加酚酞指示液3滴与0.02N 氢氧化钠液0.3ml,应显粉红色。而注射液是用电位法测定,pH 值应为4.5～6.5。在实验过程中发现将甘露醇原料配成与注射液相同浓度(20%)及各种不同浓度,分别用邻苯二甲酸氢钾标准缓
When we examined the acidity, clarity and oxalate content of mannitol in accordance with the provisions of the Chinese Pharmacopoeia 1977 edition, we found that there were some problems in the experimental conditions and proposed improvements. First, the acidity test Mannitol acidity check, according to the Chinese Pharmacopoeia method is to take this product 5g, plus new boiling cold distilled water 50ml dissolved, add phenolphthalein indicator solution 3 drops and 0.02N sodium hydroxide solution 0.3ml should be significantly pink color. The injection is determined by the potential method, the pH value should be 4.5 ~ 6.5. In the course of the experiment found that the mannitol ingredients dubbed the same concentration and injection (20%) and a variety of different concentrations, respectively, with potassium hydrogen phthalate standard slow