目的：探讨人类疱疹病毒６型（ＨＨＶ６）与血液病患者巨噬细胞集落刺激因子（ＭＣＳＦ）异常表达的关系。方法：以卵白素生物素复合物（ＡＢＣ）免疫酶标和逆转录聚合酶链反应（ＲＴＰＣＲ）方法检测３０例血液病患者骨髓单个核细胞体外感染ＨＨＶ６后ＭＣＳＦ和ＭＣＳＦｍＲＮＡ的表达。结果：ＨＨＶ６感染组ＭＣＳＦ阳性细胞百分率、积分值和ＭＣＳＦｍＲＮＡ检出率分别为３６．９％±２４．９％，４５．９±３１．４和８３３％，显著高于对照组（２０．３％±１９．４％，２５．３±２４．２，５０．０％）（Ｐ＜０．００１）；其中急性白血病组和慢性粒细胞白血病组ＭＣＳＦ表达升高幅度较大。ＭＣＳＦ主要分布于粒细胞和单核细胞的胞膜和胞浆。结论：体外感染ＨＨＶ６可以使血液病患者骨髓单个核细胞ＭＣＳＦ表达升高 Objective: To investigate the relationship between human herpes virus type 6 (HHV6) and abnormal expression of macrophage colony-stimulating factor (MCSF) in patients with hematological diseases. Methods: Bone marrow mononuclear cells from 30 patients with hemopathy were tested for in vitro infection of H-CSF with HvV-6 by immunoblot and reverse transcription polymerase chain reaction (RT-PCR) of avidin-biotin complex (ABC) M  CSF mRNA expression. Results: The positive rates of M-CSF positive cells in HHV6 infection group were 36.9% ± 24.9%, 45.9 ± 31.4 and 833% respectively, which were significantly higher In the control group (20.3% ± 19.4%, 25.3 ± 24.2, 50.0%) (P <0.001). The expression of M-CSF in acute leukemia group and chronic myeloid leukemia group High amplitude. M-CSF is mainly distributed in the cell membrane and cytoplasm of granulocytes and monocytes. Conclusion: In vitro infection of HHV 6 can hematopoietic cells in patients with bone marrow mononuclear cells C-CSF expression increased